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Major Milestones in vaccine   development and licensing in IndiaMajor milestones in          vaccine development in India










                                                          Efficacy trials onEfficacy trials on         First plagueFirst plague         First vaccine researchFirst vaccine research         Pasteur Ins tute of India.               DPT, DT and TT                     Drug and Cosme cs
                                                                                                vaccine discovered
                                                     cholera vaccine conducted
                                                                                                                                 ins tute established at Kasauli,
                                                     cholera vaccine conducted                  vaccine discovered              institute established at Kasauli,                      Coonoor, manufactured neural           Vaccine became available                    Act enacted
                                                            in Agra. India                        by Dr. Ha ine                        Himachal Pradesh                                    ssue an -rabies vaccine                  in the country
                                                                                                   by Dr. Haffine
                                                            in Agra. India
                                                                                                                                       Himachal Pradesh
                                                                                                                                             1904/
                                                               1893                                   1897                                   1904/                                                 1907                                 1920-                               1940
                                                                                                      1897
                                                               1893
                                                                                                                                              1905
                                                                                                                                              1905                                                                                      1939













                                                                                                                                                                                            Founding of Serum
                                                                                                                                               Freeze dried BCG
                                                                                                                    Indigenous OPV
                                                 UIP stated with six
                                                                               AEFI surveillance system
                                       BCG vaccine laboratory              Liquid BCG vaccine              Live attenvated freeze              Freeze dried BCG                           Ins tute of India, Pune      Live attenvated freeze         Liquid BCG vaccine            BCG vaccine laboratory
                                            antigens (BCG, OPV, DT &
                                                                                 established and initial
                                                                                                                                               vaccine and OPV
                                                                                                                     Trivalent (sabin)
                                           set up in Guard;             became available in India          dried smallpox vaccine              vaccine and OPV                                                        dried smallpox vaccine       became available in India           set up in Guindy;
                                                                                                                 developed & produced
                                                                               guidelines were released
                                                                                                                                               became available.
                                                 Measles in 1985)
                                       near Madras (Chennai)           as part of mass campaigns             became available                  became available.                                                         became available          as part of mass campaign         near Madras (Chennai)
                                                       1985/                                                                                                                                      1966                                                      1951                            1948
                                                                                                                                                     1967
                                                1948   1988                       1951   1984                      1965   1970                       1967                                                                      1965






                                                      Indian Vaccine CompanyIndian Vaccine Company
                                                    Limited (IVCOL) and Bharat
                                                    Limited (IVCOL) and Bharat         First ever recombinant                                       A fully-liquid                                                                                                               Development of
                                                  Immunologicals and Biologicals          DNA hepa  s B              First vero cell culture          wP_based                                                                Launch of H1N1 vaccine,                            Meningococcal
                                                  Immunologicals and Biologicals
                                                                                                                   Rabies vaccine launched
                                                   Limited (BIBCOL) were set up               First ever recombinant                    Panacea Biotec                                   Two Indian Manufacturers              first indigenous vaccine                       polysaccharide Vaccine
                                                                                                                                                     Pentavalent
                                                   Limited (BIBCOL) were set up
                                                                                               vaccine
                                                                                                                    by Human Biologicals
                                                                                                                                                  Vaccine launched
                                                        as public private joint              DNA hepatitis B vaccine           Pentavalent Vaccine launched by                            developed influenza flu                  against swine flu by                        Group A & C (Bi Meningo)
                                                        as public private joint
                                                                                                developed in India
                                                                                                                                     A fully-liquid wP_based
                                                         venture companies             developed in India by            Limited (HBL)            by Panacea Biotec                         vaccine (Hib PRO, Hib)                 Cadila Healthcare                                by Bio-Med
                                                         venture companies
                                                               1989                            1997   1997                   2000            2005       2005                                       2007                                 2010                                          2011
                                                               1989







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